The 25-year-old actor was found dead at his home in Los Angeles on Tuesday morning, according to TMZ.com.
The cause of death has not been determined, however, Renfro has had a history of drug abuse.
The Client star had been working to stay clean and sober after a string of drug offences, including attempted heroin possession.
The actor was accused of violating his probation after failing to enroll in a drug treatment program, following his conviction for attempted possession of heroin last summer.
A Los Angeles Superior Court Judge and L.A. Deputy District Attorney warned Renfro that if he failed to enroll in a 18-month to three-year outpatient program he would be jailed.
This was the second time Renfro had violated his probation.
Renfro pleaded guilty to the charge of attempted possession in February 2006 after he was caught in a police sting in December 2005.
At one point, Renfro was considered among the hottest stars in Hollywood; he was named The Hollywood Reporter's Young Star and one of People magazine's Top 30 Under 30 in the mid 1990s.
Ironically, he was inspired to become an actor after starring in a school production sponsored by drug organization DARE, aimed at teaching kids about
the dangers of drugs.
He first found himself in trouble with the law for his drug problems in 1998 when he was arrested in his native Tennessee, when police pulled him over and allegedly found cocaine and marijuana in his pants and socks.
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