The 44-year-old actor fell out with his dad in 2007 following a fight at the family home, which ended with Ryan firing a shotgun into the stairwell.
Griffin, who was banned from O'Neal's partner Farrah Fawcett's funeral in June (09), has sensationally blamed his dad for his lifelong battle against drugs.
He tells U.S. chat show Larry King, "I have had a lifetime of hellacious night crying, staying up too late, wondering what I did to my life. It destroyed me. It wasted many, many years of my life.
"I was 11 years old when he gave me cocaine and said we are going to see a long movie called Barry Lyndon. He said 'It is a very long movie. Maybe this will help you'. I was 11. I could never, ever do that to my child.
Griffin also slammed the 68 year old for being responsible for his sister Tatum and half-brother Redmond's drug-taking.
He adds, "Redmond hung out with Ryan a lot, because Ryan allowed the drug use. He allowed drug use in the house. They party together. They were both arrested. My dad had more dope on him than Redmond did. And that was one of the reasons me and my dad fought. I said, 'You know what? You are killing your son. I don't think you know what you're doing'.
Redmond is currently in a Los Angeles prison on drug offences, while Tatum insists she is now clean.