Motherhood has so far eluded the stunning 40 year old, who has been married once - to now father-of-six Brad Pitt.
She is currently preparing for her next movie, The Baster, which tells the story of an unmarried woman who decides to go down the insemination route to have children.
And when quizzed whether she would ever follow the same path by Entertainment Tonight, Aniston admits she would think about it as a viable option.
She replied, "I'm ready for anything. Bring it on. I wouldn't rule anything out."
But the star made it clear she'd hope to do things naturally before turning to other methods: "It would not be my first choice."