The actor made a triumphant return to the big screen last year (08), with a starring role in The Wrestler, after more than a decade struggling with drug addiction and alcoholism.
Rourke also battled through a messy divorce with actress Carre Otis in 1998, following a turbulent relationship.
But the star is thankful he was surrounded by supportive friends, who helped him through the bad times.
He says, "A lot of those who let you down are those who seemed the closest to you. They're the ones running out of your house with the silver when it all goes wrong, and when they jump ship that hurts. There are some people who stuck with me: Sly Stallone has always been a good friend to me. Stevie Jones - he's a good man. Mick Jones, Paul Simonon and Joe Strummer - God rest his soul - from The Clash: they were my guys. And we had a great time."
And Rourke has found a new pal in British actor Jason Statham, after filming scenes together for their new movie The Expendables.
He adds, "I just did a few days with Jason Statham on Sly's new film and he's become a good friend."