The Oscar winner toasted the milestone on her U.S. TV talk show The View by inviting one of her favourite authors, Stephen King, to drop by for a chat.
But it was the musical dedication from the beloved R&B band which had the actress dancing and singing along, beaming from ear to ear.
Kool & The Gang performed their 1980 disco classic Celebration, with lead vocalist James 'J.T.' Taylor changing the lyrics to honour Goldberg, singing: "A celebration to Whoopi Goldberg and all The View/We gonna celebrate and party with you."
The show's guests then joined the studio audience to sing Happy Birthday to Goldberg, before she was presented with a custom-made three-tiered cake by TV chef Duff Goldman.