The comedy, about a man who gets the chance to rewrite his life by returning to his youth, contains almost 100 goofs and continuity errors.
Harry Potter and the Half-Blood Prince and Transformers: Revenge of the Fallen tie for second place with 71 blunders, while Night at the Museum: Battle of the Smithsonian and The Twilight Saga: New Moon round out the top five, with 29 mistakes each.
The survey, by film website moviemistakes.com, also revealed disaster movie 2012 has 27 errors while Nicolas Cage's sci-fi blockbuster Knowing has 25.
In total, eagle-eyed film fans spotted more than 900 gaffes in movies released during 2009.
Moviemistakes editor Jon Sandys says, "This isn't meant to be assigning blame - generally these are noticed by the biggest movie fans, even in films they loved. That said, you wonder how some of these blunders get past the editing room."