Depp was named the Favourite Movie Actor and his Sweeney Todd co-star Sacha Baron Cohen honoured him with the Favourite Movie Actor of the Decade prize.
Baron Cohen revealed the event organisers decided to give Depp the special award after realising more people had voted for him in the past 10 years than any other celebrity.
Meanwhile, Bullock was named Favourite Movie Actress, while her film The Proposal won the Favourite Comedy Movie prize.
Laurie claimed the Favourite TV Drama Actor honour for House, which picked up the night's Favourite TV Drama award.
It was also a big night for Hugh Jackman, who landed the night's Favourite Action Star and Twilight's Taylor Lautner, who was named Favourite Breakout Movie Actor.
Music awards went to Mariah Carey (Favourite R&B Artist), Carrie Underwood (Favourite Country Artist), Keith Urban (Favourite Male Artist) and Taylor Swift (Favourite Female Artist).
Over 60 million film fans, music lovers and TV watchers voted for the awards.
The winners were:
Favourite Talk Show - The Ellen DeGeneres Show
Favourite Comedy Movie - The Proposal
Favourite R&B Artist - Mariah Carey
Favourite TV Comedy Actor - Steve Carrel (The Office)
Favourite TV Comedy Actress - Alyson Hannigan (How I Met Your Mother)
Favourite TV Comedy Show - The Big Bang Theory
Favourite TV Drama - House
Favourite TV Drama Actor - Hugh Laurie (House)
Favourite Movie Actress - Sandra Bullock
Favourite Movie Actor - Johnny Depp
Favourite Action Star - Hugh Jackman
Favourite Independent Film - Inglourious Basterds
Favourite Breakout Movie Actor - Taylor Lautner (The Twilight Saga: New Moon)
Favourite Male Artist - Keith Urban
Favourite Female Artist - Taylor Swift
Favourite Country Artist - Carrie Underwood
Favourite Web Celeb - Ashton Kutcher
Favourite New TV Drama - Vampire Diaries
Favourite New TV Comedy - Glee
Favourite Movie Actor of the Decade - Johnny Depp.