The hip-hop star has reportedly arrived in his homeland to help those left homeless and desperate after the 7.3 quake, which shook the nation on Tuesday (12Jan10).
Wyclef spent much of last night urging fans and followers to text YELE to 501 501 - each text is worth $5 (£3.10), and Alba was among the first celebrities to lend her support.
She writes, "My 1000th tweet is for the people of Haiti. Donate for the Earthquake relief for Haiti visit www.yele.org."
Ben Stiller and celebrity couple Angelina Jolie and Brad Pitt, who have worked with Wyclef's organisation in the past, have also pledged their support.
The former Fugees star took to Twitter.com to write, "I am on my way to the D R (Dominican Republic) to get to haiti. Please urge your council men governors etc we need a state of emergency for haiti (sic)."
Initial reports suggest the earthquake may have claimed as many as 500,000 lives. It's the worst quake in Haiti for over 200 years.