Avatar claimed six honours, including all the night's technical awards, Inglourious Basterds picked up three and The Hurt Locker doubled up with two of the event's biggest awards for Best Directing (Kathryn Bigelow) and Best Picture.
Nine was the night's big flop - the musical was completely shut out, despite scoring 10 nominations last month (Dec09).
The night's double winners were Up and Crazy Heart, for which Jeff Bridges claimed the Best Actor honour.
The event threw up a moment of drama when both Sandra Bullock and Meryl Streep were named Best Actress - the stars pretended to stage a tense face off on stage at the Hollywood Palladium.
The list of winners is:
Best Acting Ensemble - Inglourious Basterds
Best Supporting Actress - Mo'Nique (Precious)
Best Action Movie - Avatar
Best Animated Feature - Up
Best Young Actor/Actress - Saoirse Ronan (The Lovely Bones)
Best Supporting Actor - Christoph Waltz (Inglourious Basterds)
Best Comedy - The Hangover
Best Song - The Weary Kind by Ryan Bingham and T-Bone Burnett (Crazy Heart)
Best Documentary - The Cove
Best Picture Made for TV - Grey Gardens
Best Foreign Language Film - Broken Embraces
Best Score - Michael Giacchino (Up)
Best Costume Design - Sandy Powell (The Young Victoria)
Best Make-Up - District 9
Best Art Direction - Rick Carter & Robert Stromberg (Avatar)
Best Visual Effects - Avatar
Best Sound - Avatar
Best Cinematography - Mauro Fiore (Avatar)
Best Editing - Stephen Rivkin, John Refoua & James Cameron (Avatar)
Best Adapted Screenplay - Jason Reitman & Sheldon Turner (Up In The Air)
Best Original Screenplay - Quentin Tarantino (Inglourious Basterds)
Best Directing - Kathryn Bigelow (The Hurt Locker)
Best Actor - Jeff Bridges (Crazy Heart)
Best Actress - Meryl Streep (Julie & Julia) & Sandra Bullock (The Blind Side)
Best Picture - The Hurt Locker
Joel Siegel Award - Kevin Bacon