Crazy Heart won for Best Song and Best Actor/Drama (Jeff Bridges), while moviemaker James Cameron was named Best Director for Avatar, which also took home the Best Motion Picture/Drama honour.
It was a big day for the sci-fi blockbuster which became the first film of the new century to claim five weeks at number one at the U.S. box office earlier in the day.
It also passed Star Wars to become the third biggest-grossing movie in America. The film has already become the second most successful film globally - behind Cameron's Titanic.
The Hangover claimed the night's other top movie award for Comedy or Musical and Robert Downey Jr. was a surprise Best Actor/Comedy or Musical winner for his turn as super-sleuth Sherlock Holmes.
Best Actress awards went to Sandra Bullock and Meryl Streep, who shared the honour and a kiss at the Critics Choice Movie Awards on Friday night (15Jan10).
Other double winners were Up, which claimed the Best Animated Feature Film and Best Score, TV drama Dexter, which picked up acting honours for John Lithgow and Michael C. Hall and TV movie Grey Gardens.
The evening was bittersweet for many celebrities, who had the earthquake disaster in Haiti on their minds.
Maggie Gyllenhaal urged everyone to give generously to charity causes, while stars paid tribute to George Clooney, who is organising a celebrity telethon on Friday night (22Jan10), on the red carpet and the stage.
And it was a big night to honour spouses with winners Sandra Bullock, Mo'Nique, Robert Downey Jr., Michael C. Hall and James Cameron fighting back tears as they honoured husbands and wives.
The full list of winners is:
Best Supporting Actress in a Motion Picture - Mo'Nique (Precious)
Best Actress in a TV Series/Comedy or Musical - Toni Collette (United States of Tara)
Best Supporting Actor in a TV Series, Miniseries or TV Movie - John Lithgow (Dexter)
Best Animated Feature Film - Up
Best Actor in a TV Series/Drama - Michael C. Hall (Dexter)
Best Actress in a TV Series/Drama - Julianna Margulies (The Good Wife)
Best Original Song/Motion Picture - The Weary Kind by Ryan Bingham & T Bone Burnett (Crazy Heart)
Best Original Score/Motion Picture - Michael Giacchino (Up)
Best Mini-Series or TV Movie - Grey Gardens
Best Actress in a Motion Picture/Comedy or Musical - Meryl Streep (Julie & Julia)
Best Actor in a Mini-Series or TV Movie - Kevin Bacon (Taking Chance)
Best Actress in a Mini-Series or TV Movie - Drew Barrymore (Grey Gardens)
Best Screenplay/Motion Picture - Jason Reitman & Sheldon Turner (Up In The Air)
Best Actor in a TV Series/Comedy or Musical - Alec Baldwin (30 Rock)
Best Foreign Language Film - The White Ribbon
Best TV Series/Drama - Mad Men
Best Supporting Actress in a TV Series, Miniseries or TV Movie - Chloe Sevigny (Big Love)
Best Supporting Actor in a Motion Picture - Christoph Waltz (Inglourious Basterds)
Best Director - James Cameron (Avatar)
Best TV Series/Comedy or Musical - Glee
Best Motion Picture/Comedy or Musical - The Hangover
Best Actress in a Motion Picture/Drama - Sandra Bullock (The Blind Side)
Best Actor in a Motion Picture/Comedy or Musical - Robert Downey Jr. (Sherlock Holmes)
Best Actor in a Motion Picture/Drama - Jeff Bridges (Crazy Heart)
Best Motion Picture/Drama - Avatar
Cecil B. DeMille Award - Martin Scorsese