Beyonce was the Los Angeles event's biggest winner, claiming six of the 10 honors for which she was nominated.
These included Song of the Year, Best R&B Song and Best Female R&B Vocal Performance awards for "Single Ladies (Put a Ring on It)."
Swift took home her first four Grammys, including the coveted Album of the Year award, and Kings of Leon's anthem "Use Somebody" earned the rockers prizes for Record of the Year, Best Rock Song and Best Rock Performance by a Duo or Group with Vocals.
The Black Eyed Peas and Jay-Z were also triple winners at the Grammys, as was the San Francisco Symphony, thanks to its album Mahler: Symphony No. 8; Adagio from Symphony No. 10.
The event's winners were overshadowed by a clutch of terrific performances from acts like Green Day, Pink, Dave Matthews Band, Beyonce and the Black Eyed Peas.
Elton John and Lady Gaga collaborated to open the show, and there were further mash-ups for Jamie Foxx, T-Pain and Slash, Mary J. Blige and Andrea Bocelli, Eminem, Drake and Lil Wayne, and Taylor Swift and Fleetwood Mac star Stevie Nicks.
The stunning collaboration was accompanied by a 3-D version of the "Earth Song" video Jackson planned to use as a backdrop during his This Is It concerts last summer.
They ended the song with their backs to the crowd, staring at images of Jackson, which were flashed onto the big screen behind them, as the audience rose to its feet to applaud the performance, which presenter Lionel Richie called "unbelievable."
Following the showstopper, Jackson's children Prince and Paris took the Staples Center stage to honor their father, a recipient of one of the night's Lifetime Achievement Awards.
In his first public speaking appearance, Prince thanked God for "watching over us these past seven months" and "our grandma and grandpa for their love and support."
Both Jackson children ended their brief acceptance speeches with the words "We love you daddy".
The big winners of the 2010 Grammys are:
Record Of The Year: Use Somebody - Kings of Leon
Song Of The Year: Single Ladies (Put A Ring On It) - Beyonce
Best New Artist: Zak Brown Band
Album Of The Year: Fearless - Taylor Swift
Best Female Pop Vocal Performance: Halo - Beyonce
Best Male Pop Vocal Performance: Make It Mine - Jason Mraz
Best Pop Performance By A Duo Or Group With Vocals: I Gotta Feeling - The Black Eyed Peas
Best Pop Collaboration With Vocals: Lucky - Jason Mraz & Colbie Caillat
Best Pop Instrumental Performance: Throw Down Your Heart - Bela Fleck
Best Pop Instrumental Album: Potato Hole - Booker T. Jones
Best Pop Vocal Album: The E.N.D. - The Black Eyed Peas
Best Dance Recording: Poker Face - Lady Gaga
Best Electronic/Dance Album: The Fame - Lady Gaga
Best Traditional Pop Vocal Album: Michael Buble Meets Madison Square Garden - Michael Buble
Best Solo Rock Vocal Performance: Working On A Dream - Bruce Springsteen
Best Rock Performance By A Duo Or Group With Vocals: Use Somebody - Kings of Leon
Best Hard Rock Performance: War Machine - AC/DC
Best Metal Performance: Dissident Aggressor - Judas Priest
Best Rock Instrumental Performance: A Day In The Life - Jeff Beck
Best Rock Song: Use Somebody - Kings of Leon
Best Rock Album: 21st Century Breakdown - Green Day
Best Alternative Music Album: Wolfgang Amadeus Phoenix - Phoenix
Best Female R&B Vocal Performance: Single Ladies (Put A Ring On It) - Beyonce
Best Male R&B Vocal Performance: Pretty Wings - Maxwell
Best R&B Performance By A Duo Or Group With Vocals: Blame It - Jamie Foxx & T-Pain
Best Traditional R&B Vocal Performance: At Last - Beyonce
Best Urban/Alternative Performance: Pearls - India.Arie & Dobet Gnahore
Best R&B Song: Single Ladies (Put A Ring On It) - Beyonce
Best R&B Album: Blacksummers' Night - Maxwell
Best Contemporary R&B Album: I Am... Sasha Fierce - Beyonce
Best Rap Solo Performance: D.O.A. (Death Of Auto-Tune) - Jay-Z
Best Rap Performance By A Duo Or Group: Crack A Bottle - Eminem, Dr. Dre & 50 Cent
Best Rap/Sung Collaboration: Run This Town - Jay-Z, Rihanna & Kanye West
Best Rap Song: Run This Town - Jay-Z, Rihanna & Kanye West
Best Rap Album: Relapse - Eminem
Best Female Country Vocal Performance: White Horse - Taylor Swift
Best Male Country Vocal Performance: Sweet Thing - Keith Urban
Best Country Performance By A Duo Or Group With Vocals: I Run To You - Lady Antebellum
Best Country Collaboration With Vocals: I Told You So - Carrie Underwood & Randy Travis
Best Country Instrumental Performance: Producer's Medley - Steve Wariner
Best Country Song: White Horse - Taylor Swift
Best Country Album: Fearless - Taylor Swift
Best Spoken Word Album: Always Looking Up - Michael J. Fox
Best Comedy Album: A Colbert Christmas: The Greatest Gift Of All! - Stephen Colbert
Best Compilation Soundtrack Album For Motion Picture, Television Or Other Visual Media: Slumdog Millionaire - Various Artists
Best Score Soundtrack Album For Motion Picture, Television Or Other Visual Media: Up - Michael Giacchino
Best Song Written For Motion Picture, Television Or Other Visual Media: Jai Ho (From Slumdog Millionaire) - Gulzar, A.R. Rahman & Tanvi Shah, songwriters
Lifetime Achievement Award: Leonard Cohen
Lifetime Achievement Award: Michael Jackson
Lifetime Achievement Award: Loretta Lynn
Lifetime Achievement Award: Bobby Darin
Lifetime Achievement Award: Clark Terry
Lifetime Achievement Award: David 'Honeyboy' Edwards
Lifetime Achievement Award: Andre Previn
Trustees Award: Walter C. Miller
Trustees Award: Florence Greenberg
Trustees Award: Harold Bradley
Presidents Merit Award: Doug Morris
Presidents Merit Award: Placido Domingo
Presidents Merit Award: Ken Ehrlich
MusiCares Person of the Year: Neil Young
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