Depp rose to fame in 1990 with his leading role in Edward Scissorhands, his first film collaboration with director Tim Burton.
He has since established himself as one of Hollywood's biggest and most bankable stars, making the Pirates of the Caribbean series one of the most lucrative franchises - but the 46 year old is astonished he's made it this far.
He tells People.com, "The whole ride - my whole ride and experience on the ride - since day one has been pretty surreal in this business. It defies logic, why I'm still here. I'm still completely shocked that I still get jobs and still am around... I've been very lucky.
"I had no idea where anything was going, but you can't. It's almost impossible to predict anything like that. I had no idea. I had hoped... But I'm luckily still here."