The star, who plays Justin Suarez in the hit U.S. show, was joined by castmates including America Ferrera, Ana Ortiz and Tony Plana at the bash at the city's Red Bull studio.
Indelicato enjoyed bowling games and ate ice-cream, while the cast presented him with a special cardboard cut-out of Mode magazine - the fictional publication featured in the series.
During the night Ferrera, who plays the title role, made a toast to Indelicato, telling the young actor she will miss him when the show ends later this year (10).
In a post on his blog following the party, the teen star writes, "I finally had my Sweet 16! It was probably the best night of my entire life. I had everyone that I love and that love me around at all times and it turned out to be so fun! My birthday party was a success and one of the nights I will remember for the rest of my life."