The Wrestler star reveals the actress in question has fooled everyone into thinking she's "a lot better than she is".
Rourke tells MovieHole.net, "I worked with an actress recently who, despite having a reputation as a good actress, s**ts herself when that little red light comes on.
"She's fooled everyone into thinking she's a lot better than she is. Working with someone like that is a pain in the a**."
One actress who definitely didn't annoy the actor was Transformers star Megan Fox - his co-star in new film Passion Play.
Rourke is confident Fox is all set to become a great star.
He explains, "It was a lot of fun. (Fox) was great to work with... I mean, look at her! And it was also great to work with someone who may be beautiful and good-looking but also knows how to do her homework. I think people will have a different perspective of her (after this film). It was great to work with someone like Megan."
Rourke's most recent co-stars, aside from Fox, include Scarlett Johansson, Olivia Munn and Gwyneth Paltrow (Iron Man 2), Isabel Lucas and Freida Pinto (Immortals), Emmanuelle Chriqui (13) and Winona Ryder and Amber Heard (Informers).