Ramin Setoodeh suggested the former Will & Grace star was "wooden and insincere" in an online article, titled Straight Jacket, about homosexuals playing it straight on Broadway.
Appalled by the piece, Chenoweth penned an open letter, defending a gay star's right to play any role, and posted it on several social network sites over the weekend (09May10).
She wrote, "I was shocked on many levels to see Newsweek publishing Ramin Setoodeh's horrendously homophobic Straight Jacket, which argues that gay actors are simply unfit to play straight.
"I'd normally keep silent on such matters and write such small-minded viewpoints off as perhaps a blip in common sense, but the offense I take to this article, and your decision to publish it, is not really even related to my profession or my work with Hayes.
"This article offends me because I am a human being, a woman and a Christian. For example, there was a time when Jewish actors had to change their names because anti-Semites thought no Jew could convincingly play Gentile.
"I know how much it means to young people struggling with their sexuality to see out & proud actors like Sean Hayes, (Glee star) Jonathan Groff, Neil Patrick Harris and Cynthia Nixon succeeding in their work without having to keep their sexuality a secret. I encourage Newsweek to embrace stories which promote acceptance, love, unity and singing and dancing for all!"