Sandra Bullock's romantic comedy The Proposal and Harry Potter and the Half-Blood Prince both received four nominations.
The Hangover, the Twilight sequel, Avatar, Alice in Wonderland and Harry Potter and the Half-Blood Prince will compete for the coveted Best Film prize when the awards are handed out on 6 June (10).
Twilight's Kristen Stewart, Robert Pattinson and Taylor Lautner all land Best Performance nods alongside Avatar's Zoe Saldana, Dear John lovebirds Channing Tatum and Amanda Seyfried, Harry Potter stars Emma Watson and Daniel Radcliffe, and Zac Efron (17 Again).
Three new awards will be added to the event - The Best Scared-as-S**t Performance, Biggest Badass Star and Global Superstar, which will pit Pattinson, Stewart, Radcliffe and Lautner against Johnny Depp.
Meanwhile, Stewart and Pattinson will compete for the Best Kiss award with Stewart and Dakota Fanning (The Runaways), Lautner and Taylor Swift (Valentine's Day), Bullock and Ryan Reynolds (The Proposal), and Saldana and Sam Worthington (Avatar).
Oscar winner Christoph Waltz has already emerged as the Best Villain - he'll battle The Hangover's Ken Jeong, Stephen Lang (Avatar), Helena Bonham Carter (Alice in Wonderland) and Tom Felton (Harry Potter and the Half-Blood Prince).