Arinze called for Christians worldwide to "do something practical" to destroy the so-called blasphemous tract, written by Dan Brown.
He slammed the controversial work as a violation of basic human rights, contending Christians should have their "religious beliefs respected."
Speaking on documentary The Da Vinci Code--A Masterful Deception, Arinze fumes, "Christians must not just sit back and say it is enough for us to forgive and to forget.
"Sometimes it is our duty to do something practical.
"Any film produced on the basis of that book is already in error from the word go, no matter how interesting it might appear."
Last month, another Vatican cardinal, Angelo Amato, demanded the Tom Hanks-starring film be boycotted.
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