The honor is given each year to a film artist "who is fully engaged in his or her work and is committed to making a significant contribution to the art of the motion picture."
Cinematheque board chairman Rick Nicita has hailed the new recipient, insisting, "George Clooney is truly a Renaissance man.
"In a relatively short time he has proven his talents as an actor, director, writer and producer.
"He has managed to blend entertainment with political commentary as well as combining charm, eloquence and good old-fashioned movie star charisma.
"His personal commitment to trying to make the world a better place is reflected both onscreen and in his off-screen social activism."
The prize giving will take place at a star-studded gala at the Beverly Hilton Hotel in California.
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