Church officials previously called for a boycott of Hanks' first outing in the thriller series - and now it looks as if the second movie in the franchise will also cause controversy because of its religious overtones, according to the Hollywood Reporter.
The Vatican's officials newspaper, Avvenire, ran a story on Friday, stating that Catholic Church "cannot approve" of the movie, with another Italian publication La Stampa, warning that officials will call for a boycott ahead of the film's release in May.
The story is set in Rome, but filming was held up after Vatican officials refused the crew permission to shoot in the religious site and at several other important locations in the city.
Angels & Demons is set to open worldwide on May 15.
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