The actor plays Harvard symbologist Dr. Robert Langdon in the big-screen adaptation of author Dan Brown's book, about the murder of a physicist and a terrorist act against the Vatican by a secret brotherhood.
The movie is a prequel to 2006's The Da Vinci Code, based on another of Brown's hit books, which came under fire from Catholic leaders who claimed the film attacked the core beliefs of their faith.
Angels & Demons has been met with similar criticism before it is even released -- but Hanks is adamant that there is nothing offensive about the film.
He tells the New York Daily News, "People will see there's nothing sacrilegious about it at all. Yes, we had a few things go on that are completely fictionalized; but there's no reason to have a big hurly-burly over what is essentially a whodunit (murder mystery).
"There's no major theological discussion that goes on, other than science versus faith. There's no winner in that argument. I just solve the murder."
Angels & Demons is set to hit theaters later this month.
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