The veteran comedian passed away in his sleep at a hospital in Los Angeles on Monday night, reports TMZ.com.
He became known on the small screen for his magic act as 'Dominick the Great' on the popular Dean Martin Show between 1972 and 1973, and went on to further establish himself in Hollywood with appearances in Mel Brooks' films such as 1974's Blazing Saddles, 1976's Silent Movie, and 1993 comedy Robin Hood: Men in Tights.
The star was also nominated for a Golden Globe in 1974 for his work on TV comedy Lotsa Luck, while he received a nod at the Daytime Emmys in 1999 for his efforts in the animated All Dogs Go to Heaven: The Series.
DeLuise spent his latter years writing children's books and cookbooks.
He is survived by his actress wife Carol Arthur, who he married in 1965, and their three actor sons Peter, David and Michael DeLuise.
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