The vampire love story's stars Robert Pattinson and Kristen Stewart picked up prizes for Breakthrough Performance (Male) and Best Female Performance, respectively, and they shared the night's Best Kiss honor at the ceremony on Sunday.
Pattinson also shared the Best Fight award with another Twilight co-star, Cam Gigandet.
The show's most jaw-dropping moment came when bare-bottomed British comedian Sacha Baron Cohen, dressed as a giant dove and in character as Bruno, fell from the roof of the Universal Amphitheater onto rapper Eminem's lap.
The prank appeared not to be a joke -- and the rapper stormed off with his entourage in tow.
The list of winners is:
Breakthrough Performance (Female) - Ashley Tisdale (High School Musical 3: Senior Year)
Best Fight - Cam Gigandet & Robert Pattinson (Twilight)
Breakthrough Performance (Male) - Robert Pattinson (Twilight)
Best Male Performance - Zac Efron (High School Musical 3: Senior Year)
Best Kiss - Robert Pattinson & Kristen Stewart (Twilight)
MTV Generation Award - Ben Stiller
Best Female Performance - Kristen Stewart (Twilight)
Best Movie - Twilight
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