The former James Bond actor teamed up with Meryl Streep and Colin Firth for the 2008 blockbuster, and movie producers were reportedly keen to cash in on its popularity with a second installment.
Last year Streep admitted she was doubtful that plans for a sequel would ever come to fruition, saying, "I heard that they were talking about it, but I am not sure it's real."
And now Brosnan appears to have lost interest.
Asked by EmpireOnline.com for an update on Mamma Mia! 2, Brosnan says, "No, I don't think that's happening."
The movie grossed more than $573 million across the globe upon its release in 2008.
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