I mean this as literally as possible, since Cooper is now suspected to take over the starring role in The Man from U.N.C.L.E., previously held by Clooney (who dropped out due to the roles' physical demands). But this could also come to fruition in a more general way. U.N.C.L.E. is not the only thing on the Hangover star's horizons. In production right now for Cooper are the drama-thriller The Words, the David O. Russell dramedy The Silver Linings Playbook (wherein he'll be ruiniting with Limitless costar Robert DeNiro), and, most excitingly, an adaptation of John Milton's Paradise Lost—which has cast Cooper as the central, and most interesting, character: The Devil.
Cooper's character in U.N.C.L.E., directed by Steven Soderbergh, will be Napoleon Solo, an American spy originated by Robert Vaughn in the 1960s television series. Cooper can do spy. He's debonair. He's light-hearted (but severe when severity is needed). He's secret agent material.
So, all this considered, Cooper's career is on a pretty steady climb, and the variety in the above projects show off the actor's versatility. Such is why dubbing him "the next George Clooney" isn't such a stretch. He's grounding himself in comedy, drama, thriller, fantasy, action/adventure...a Cooper-driven mystery sci-fi would be something I'd look into.
This could be the start of the next big Hollywood icon. And to think, it all started back in Camp Firewood.