There was even an honor for the cast of 1980 teen hit The Breakfast Club who were reunited by organizers and serenaded onstage at Hollywood's Shrine Auditorium.
Leonardo DiCaprio was named Best Male, and Mean Girls star Lindsay Lohan Best Female.
Actress Rachel Mcadams was the biggest individual winner, taking three prizes--Best Breakthrough Female Performance for Mean Girls, Best Kiss for The Notebook and a third along with the entire cast of Mean Girls.
But she had to share the limelight with Napoleon Dynamite's Jon Heder, who received two awards: Breakthrough Male Performance and Best Musical Performance for the film, which won Best Film.
The ceremony also paid host to the hottest Hollywood romance of the moment, with Katie Holmes handing out a Lifetime Achievement award to her new beau Tom Cruise.
Cruise told the crowd, "If I've been able to entertain you at all, okay? Then, I thank you for allowing me to do so."
Elsewhere, child star Dakota Fanning won Best Frightened Performance for Hide & Seek and Dustin Hoffman scooped the Comedic Performance for Meet The Fockers.
The show was taped Saturday and will be broadcast June 9 on MTV. Here is the list of nominees:
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BEST MOVIE
Kill Bill Vol. 2
Napoleon Dynamite
Spider-Man 2
Ray
The Incredibles
BEST MALE PERFORMANCE
Jamie Foxx, Ray
Will Smith, Hitch
Brad Pitt, Troy
Matt Damon, The Bourne Supremacy
Leonardo DiCaprio, The Aviator
BEST FEMALE PERFORMANCE Uma Thurman, Kill Bill Vol. 2
Lindsay Lohan, Mean Girls
Hilary Swank, Million Dollar Baby
Rachel McAdams, The Notebook
Natalie Portman, Garden State
BEST COMEDIC PERFORMANCE
Antonio Banderas, Shrek 2
Dustin Hoffman, Meet the Fockers
Will Ferrell, Anchorman: The Legend of Ron Burgundy
Ben Stiller, Dodgeball: A True Underdog Story
Will Smith, Hitch
BEST ON-SCREEN TEAM
Lindsay Lohan/Rachel McAdams/Lacey Chabert/Amanda Seyfried, Mean Girls
Craig T. Nelson/Holly Hunter/Spencer Fox/Sarah Vowell, The Incredibles
Will Ferrell/Paul Rudd/Fred Armisen/Steve Carell, Anchorman: The Legend of Ron Burgundy
Vince Vaughn/Christine Taylor/Justin Long/Alan Tudyk/Stephen Root/Joel David Moore/Chris Williams, Dodgeball: A True Underdog Story
John Cho/Kal Penn, Harold & Kumar Go to White Castle
BEST VILLAIN
Tom Cruise, Collateral
Ben Stiller, Dodgeball: A True Underdog Story
Rachel McAdams, Mean Girls
Jim Carrey, Lemony Snicket's A Series of Unfortunate Events
Alfred Molina, Spider-Man 2
BREAKTHROUGH MALE
Jon Heder, Napoleon Dynamite
Tim McGraw, Friday Night Lights
Zach Braff, Garden State
Freddie Highmore, Finding Neverland
Tyler Perry, Diary of a Mad Black Woman
BREAKTHROUGH FEMALE
Rachel McAdams, Mean Girls
Ashanti, Coach Carter
Elisha Cuthbert, The Girl Next Door
Bryce Dallas Howard, The Village
Emmy Rossum, The Day After Tomorrow
BEST KISS
Rachel McAdams & Ryan Gosling, The Notebook
Natalie Portman & Zach Braff, Garden State
Gwyneth Paltrow & Jude Law, Sky Captain and the World of Tomorrow
Jennifer Garner & Natassia Malthe, Elektra
Elisha Cuthbert & Emile Hirsch, The Girl Next Door
BEST ACTION SEQUENCE
Destruction of Los Angeles, The Day After Tomorrow
The Subway Battle. Spider-Man 2
Beverly Hills Plane Crash, The Aviator
The Moscow Car Chase. The Bourne Supremacy
The Desert Terrorist Assault, Team America: World Police
BEST FIGHT
The Battle of the News Teams, Anchorman: The Legend of Ron Burgundy
Daryl Hannah vs. Uma Thurman, Kill Bill Vol. 2
Brad Pitt vs. Eric Bana, Troy
Ziyi Zhang vs. The Emperor's Guards, House of Flying Daggers
BEST MUSICAL PERFORMANCE
Jennifer Garner & Mark Ruffalo, "Thriller Dance," 13 Going On 30
Will Ferrell/Paul Rudd/Fred Armisen/Steve Carell, "Afternoon Delight," Anchorman: The Legend of Ron Burgundy
John Cho & Kal Penn, "Hold On," Harold & Kumar Go to White Castle
Jon Heder, "Election Dance," Napoleon Dynamite
BEST FRIGHTENED PERFORMANCE
Cary Elwes, Saw
Sarah Michelle Gellar, The Grudge
Jennifer Tilly, Seed of Chucky
Mya, Cursed
Dakota Fanning, Hide and Seek
BEST VIDEO GAME BASED ON A MOVIE
Spider-Man 2
Van Helsing
Chronicles of Riddick: Escape from Butcher Bay
Harry Potter and the Prisoner of Azkaban
The Incredibles
