The studio has asked online video site Broadcaster.com to take down three animated clips, titled The OJ Simpsons, that re-imagine the series with the ex-American footballer.
The three clips are titled Black and White Christmas, Warzone and If I Did It--which features Fox's decision to withdraw publication of Simpson's proposed book about the murder of his ex-wife, Nicole Brown Simpson, and her friend Ronald Goldman.
The clips also parody the opening scene of The Simpsons, with Simpson being chased by several police cars - just like he was chased live TV in the US, after the pair were found dead in Los Angeles in June 1994. Simpson was later found not guilty of the murders.
The Web site offered to review the clips, but claim parodies are protected by fair-use doctrine. Chief-executive Martin Wade said: "We respect the rights of content owners.
"Our goal is to be a respecter of content rights and at the same time find legal ways to bring our community members the content they enjoy."
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