After picking up her first prize--the comedienne's show also won the Best Talk Show award--DeGeneres praised presenter Rosie O'Donnell, who quit talk show The View after a bust-up with co-host Elisabeth Hasselbeck.
She said, "I liked what she did. This was the year she should have won. I wanted to acknowledge Rosie because she has done a lot."
Other winners included the newly retired Bob Barker for Best Game Show Host.
The Best Soap Award was split between two nominees for the first time ever--after judges couldn't decide a winner from Guiding Light and The Young and the Restless.
The Best Performer in a Children's Series category was also split--between Sesame Street's Oscar the Grouch and Elmo, played by Caroll Spinney and Kevin Clash.
Last night's ceremony took place at Hollywood's Kodak Theatre--the home of the Academy Awards.
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