The A League of Their Own star was scheduled to sit down with news anchor Diane Sawyer for a segment on Good Morning America in the beginning of October, but O'Donnell's publishers have mysteriously pulled the plug on the much-anticipated interview.
No details concerning the reason for the cancellation have been released.
A spokeswoman for Good Morning America says, "We were informed by the publisher today that she (O'Donnell) has cancelled all her media appearances."
Writing on her blog on Friday, O'Donnell told fans she didn't feel ready to "discuss or defend" the things in her new book.
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