Murray's career took off in 2003 with the TV series, which has been renewed for an upcoming seventh season.
But the 27-year-old actor has announced that his character, Lucas Scott, is set to leave the teenage drama, claiming in a video posted on YouTube that bosses have opted not to renew his contract, reports the New York Post.
The context of the video, which was removed from the Web site on Monday, remains unknown.
Murray remarks, "They're not bringing me back next year... because they want to save money. They don't want me. I'm not joking. This is actually the last scene we're shooting, right now."
Network bosses have yet to comment on which actors will return for the show's next season.
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