Leno will depart the show on Friday after 17 years as the king of late-night TV, and his best bits have been recapped by Entertainment Weekly magazine.
Grant's interview after he was caught with Hollywood prostitute Divine Brown beat President Barack Obama's history-making appearance in March (scroll down to watch the clip) and Arnold Schwarzenegger's interview in 2003 when he announced his candidacy for California Governor.
Leno raised laughs when he opened his July 1995 talk with Grant by asking the British actor, "What the hell were you thinking?"
President Obama's interview in March marked the first time a sitting president had appeared on a late-night talk show.
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