Entertainment Weekly reported that Knight had asked to terminate his contract with bosses of the medical drama on Wednesday, and now George has become the first castmate to comment on his departure.
She tells UsMagazine.com, "He's one of my best friends. I feel great for him. He's had a good week."
Knight's character, George O'Malley, appeared to die in the most recent season finale after he was hit by a bus.
The actor is reportedly in talks to headline the Broadway revival of Lend Me a Tenor in 2010.
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