Rogen was left fuming after Entourage characters referred to his "oddly fascinating" ugliness, questioning whether the funnyman could ever win a date with a stunner such as actress Katherine Heigl, his love interest in Knocked Up.
But filmmaker Apatow insists the jibes were made deliberately to highlight how average the actors on the hit series are.
He says, "I thought it was great on Entourage because it's a wonderful self-referential joke. Goofy guys on Entourage debating whether or not goofy guys can get hot girls when those guys have been getting gorgeous girls for the last half a decade!
"The whole subject is ridiculous. I'm in my Manhattan hotel room right now and can walk outside and, within minutes, could see 25 couples in which one person is insanely better looking than the other."
And Apatow, who is married to actress Leslie Mann, insists it isn't rare for gorgeous women to find love with funny men: "That aspect's been in movies for years. Take Woody Allen and Diane Keaton in Annie Hall. Better yet, look at me! All I have to do is take a look at my wife in the other room!
"I don't think odd-looking couples are a new thing or even a myth. Unless, of course, I've gotten incredibly handsome and nobody's told me."
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