The former Cheers actor has struggled to resurrect his career after his long-running spinoff series Frasier ended in 2004.
Grammer's last comedy outing, Back to You, was scrapped in 2008 after just 17 episodes.
And now Hank, in which Grammer played a tycoon forced to reconnect with his family after losing his job, has met the same fate.
Executives at ABC have confirmed the show has been shelved after it struggled in ratings during its first few weeks.
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