In an effort to make sure Sheen could never return to Two and a Half Men, producers decided to kill off the Charlie character violently and unsympathetically; thus, the premiere will open with Charlie's funeral. But you all already knew that. So how do they do it? Murder. But "justified" murder.
Over the course of the summer, Charlie Harper and his fiance Rose (Melanie Lynskey) have eloped to Paris. While on their honeymoon, Rose finds Charlie in the shower with another woman. In a fit of calculated rage, Rose pushes Charlie onto the tracks of a French subway, where he is killed. Rose will pass this off as an accident, and probably never face any ramifications (to further instill the producers' philosophy that killing any incarnation of Sheen is all G in the H).