The star was first diagnosed with myalgic encephalomyelitis (ME) when she was in a violent relationship in her teens, but the symptoms, which include extreme exhaustion and headaches, disappeared as she entered her 20s.
However, after shooting long hours on her chat show, which featured in-depth discussions with the likes of Lady Gaga and Gwyneth Paltrow, the autoimmune illness came back with a vengeance.
She tells Britain's You magazine, "I had no symptoms of it for about 15 years and then it came back right after we finished making The Conversation. I suffered from exhaustion, memory loss, dizziness, fever and swollen glands. There's only a small team of us on the show and I think we worked so hard that I was worn down."
It's an age-old story: Girl becomes teenage millionaire. Girl grows up. Girl shows her boobs.
Getting engaged to Hunger Games hunk Liam Hemsworth certainly hasn't slowed Miley Cyrus down. The 19-year-old wild child actress/singer has been out and about in full force, showing off more than that big honking diamond ring.
"For me, what I do [being sexy] is not the point," she recently told Lifetime's The Conversation With Amanda de Cadenet. "You're not sitting there trying to be sexy. If people find that [I am], I take it as a compliment. People are so scared of seeing a woman being like, ‘This is who I am and you’re not going to change it.’”
What do you think? Are you digging Miley's new half-naked look?
Have a peek at some of her recent anti-outfits:
The Classic Side Boob
The two friends were shooting the chat for De Cadenet's The Conversation talk show when the topic turned to parenting - and the British socialite became emotional as she thanked the star for helping her cope with motherhood.
De Cadenet said, "I very much trust your instinct and guidance as a mother. I was thinking about the things that I've learned from you and one of the things is really about family.
"I didn't grow up with that; I didn't have a relationship with my father and, like, learning to be a mother to a son and a daughter when there isn't really an example, and how I watched you with your kids... I really learned so much from you."
De Cadenet halted the interview and apologised for the sudden emotion, prompting her pal to joke, "This is the worst interview of all time... I'll start crying."
The host added, "I'm so grateful for that... I've been able to witness how you juggle everything and how you show up for your son and your daughter and I've often looked at you and thought, 'How do you know how to do this?'"
The Hollywood couple celebrated the milestone anniversary last year (11), when the stars became parents for the third time to son Benjamin, but Preston admits it hasn't always been an easy ride and they have had to work on maintaining a loving relationship through the years.
In an interview with socialite Amanda De Cadenet for her U.S. show The Conversation, Preston says, "Really in life, to stay married (you have) to keep finding out about the person and wanting to be together, because there's so many things that you work through... Going through huge highs and amazing lows, and being able to navigate that... and keep checking in and creating it (a strong relationship), because it doesn't happen on its own."
Preston insists keeping each other laughing has been the key to their relationship: "A marriage, people think, 'Oh, you just let it happen.' No, you need to create it and keep it fun and keep it alive and funny. We laugh, I think that's one of our biggest things together."
And the actress reveals she still finds herself physically attracted to Travolta, whatever shape he's in.
She adds, "He's hot... He looks amazing now, he's lost so much weight and he's been working out, but yet I love him when he was 20 pounds heavier, and thought he was really hot."
Preston's comments, which aired in the U.S. on Thursday (14Jun12), emerge just weeks after the couple found its union under scrutiny following unfounded allegations accusing the Grease actor of sexually assaulting two male masseurs in separate incidents earlier this year (12). Travolta's attorney slammed the claims and the lawsuits were subsequently withdrawn.
The actress decided to take immediate action when doctors diagnosed her with an early form of the disease in 2008 and she regained her figure after having reconstructive surgery.
But Applegate, 40, admits having fake boobs did little for her self-esteem and she feels no emotional connection with her new chest.
In a candid U.S. TV talk with The Conversation host Amanda de Cadenet, she says, "It just is different (having fake breasts). I think at first I was pretty OK with them, as far as just they stood up, they didn't move, I could wear tank tops without a bra, but to be honest, this section of my body (her chest) I'm just very disconnected with. It's just a strange thing."
The actress admits she finds breasts fascinating and urges all women to do what they need to do to have the best boobs.
She says, "Buy yourself a pair of t**ties... I heard somebody tell me this once and I thought, 'You know what, you're absolutely right. Thank you for that.' It just hit me. Why not... Buy yourself a pair of t**ties.
"It's the same way an old man who's having, like, a mid-life crisis can buy a Porsche and date, like, a 17 year old, I can buy myself a pair... and be the sexiest soccer mom."
Appearing on socialite Amanda de Cadenet's new U.S. talk show The Conversation on Thursday night (26Apr12), Saldana confessed she loves watching empowered bra-less women bouncing down the street: "I love when you can showcase (your breasts). It doesn't matter how flat or how big or saggy or crooked or whatever; just be proud of them and just show them. Go up and down the stairs without a bra and just let them hang. I think it's so sexy and empowering."
Gwyneth Paltrow, Zoe Saldana, Jane Fonda and comedienne Sarah Silverman were all asked about what makes them most comfortable in intimate settings.
The racy question raised eyebrows for Fonda and prompted de Cadenet's longtime pal Paltrow to shriek, "What?" - but they all answered.
Silverman said, "I do enjoy a good sound missionary-ing... and I like to be manhandled," while Star Trek pin-up Saldana replied, "I like missionary and I like being on my knees too. And I love being on top... I love doggy-style or standing up."
Candid Fonda offered: "While I am quite flexible and I can kneel, it's not quite as comfortable for me as it used to be before I had a fake knee... (I like to be) either lying down or sitting up on a couch with him coming on to me, no pun intended."
After her initial shock, Paltrow added, "I'm down with all of them."
The Conversation debuted on Thursday night (26Apr12).
The actress admits she has always dreamed of a brood of kids but the timing was never right for her to get pregnant during her 11-year romance with Britton, which ended last year (Nov11).
In a candid interview with socialite Amanda de Cadenet for new U.S. show The Conversation, Saldana says, "I'm Latin, we start young... At 22, you're like, 'I'm getting an itch to hold something; I just wanna have a little critter.'
"I was dating my partner and you wanna be respectful... he wasn't ready... and then when he got ready I didn't have time.
"Making the decision to wait with him was one of the most mature things... Had I been, like, the traditional person that I really am, I would have been, 'I'll find somebody that can give me a baby...' I'm glad that I respected him."
But now the 33-year-old actress is desperate to be a mum: "I want two or three or four or five. I don't care. They're so delicious and I love the pressure and anxiety of, like, a loud room full of yapping kids. I'm a kid myself, so I get along very well with animals and children. I dig them, I get them. They make perfect sense to me."
The Indecent Proposal star has endured a tough few months following her split from husband Ashton Kutcher in November (11) and has been keeping a low profile since her hospitalisation in January (12) and subsequent stint in a clinic to treat exhaustion.
However, Moore returned to Twitter this week (beg16Apr12) after a prolonged absence and she stepped back into the public eye by attending the Tuesday night red carpet launch of her friend Amanda de Cadenet's new TV show.
The actress supported her pal at the party in Los Angeles for new series The Conversation, which she executive produces, and posed for pictures on the red carpet.
De Cadenet also revealed how pleased she was to have her friend onboard, telling E! Online, "Demi is one of my best girlfriends and a great sounding board for me. She's got 10 years on me, and so she is more ahead of me in the game of being a woman.
"She is an amazing resource for me, and so she has a vast life experience that I love to experience and to hear...
"It was amazing to go to work with someone that I am so close to. It's really cool to be able to do that. She is really enjoying going behind the camera, she's a really good director... She's not someone that's like, 'Oh I can't make that phone call.' If she's on she's on, she's in. She doesn't do things half-a**ed. It was great to have her involved."
Moore's health troubles began with a medical emergency at her Los Angeles home in January (12), when she reportedly suffered convulsions, and she later spent a month at the Cirque Lodge Centre in Utah. Her publicist claimed the actress was battling exhaustion and checked into the clinic in a bid to "improve her overall health".
The Ghost star will launch interview series The Conversation next month (Jan12), with British TV personality Amanda de Cadenet serving as the programme's host.
The Lifetime Network show will have a women's empowerment theme and feature a number of celebrity guests, including Lady Gaga, Gwyneth Paltrow and Olivia Wilde.
Moore, who recently split from husband Ashton Kutcher, is only billed as a producer on the show, but she may also take on an on-camera role, according to the New York Daily News.
A source tells the publication, "It's been an emotional year for her, and people want to hear what she has to say."