Miniseries based on the non-fiction book by David Simon and Edward Burns about a black family and the changes they experience over decades in Baltimore. The story focuses on Gary McCullough, Fran Boyd and their 15-year-old son DeAndre McCullough. They live amid an open-air drug market on West Baltimore's Fayette Street that has all but destroyed the row house neighborhood. Gary is fighting a heroin addiction and struggling for survival. Fran, a tough, clever woman, struggles daily with her own addictions as she tries to be a mother to DeAndre, who is fighting his own battle against the lure of the drug corners that define his world.