Tara Talbot, 17 years old, is a sideshow spectacle. As a victim of hypertrichosis, a skin disease associated with excessive hair growth all over the body, Tara has always been an outcast among her peers. In a small town while performing as the "Wolf Girl" in her circus sideshow, she becomes the victim of cruel pranks by a local teenage gang led by Beau. Ryan, a town youth, is drawn to Tara; he tells her that his mother has developed a serum that depletes hair. She begins taking the serum; her behavior becomes erratic and unpredictable, but she does begin to lose hair. Tara's "Wolf Girl" performances become more wild; she breaks down her stage case and practically tears out Beau's throat. As her exterior begins appearing normal, her internal emotions become more bestial. Strange animal attacks surface around town, and rumors spread about a wolf prowling around in the neighborhood. When a human victim is found, citizens begin to wonder if it is a wolf, or the wolf girl reaping havoc.