House and the team take on the case of a man, living with severe chronic pain, who tries to take his own life after living for years without a diagnosis or any relief from his suffering. Parallels between the patient and House's experiences with prolonged pain become apparent. When the patient attempts suicide again, the search for answers becomes more urgent. Meanwhile, Foreman and Thirteen explore their relationship as they work together on the Huntington's disease drug trial. Cuddy finds that taking care of her adopted baby leaves her little time to run the hospital and look after House at the same time.