The house guests arrive and are informed they will be selecting the HoH before moving in. Jerry is elected HoH. Jessie and Renny argue over the noise Renny is making. Brian and Dan make friends and Brian tries to dissuade Jerry from nominating Dan. Jerry nominates Renny and Jessie due to their conflict.
Jerry apologizes for the nominations and tries to explain himself. Then he has everyone up to his room for some wine where Renny apologizes to Jessie again for waking him.
Brian is evicted. The rest of the guests compete for HoH and Jessie wins the title.
Jessie moves into the HoH room putting up pictures of himself instead of his family. Jerry confides to Angie and Libra that his wife has Parkinson's Disease. Dan, Angie, Steven, Ollie, Michelle and Jessie win the food competition. Jessie nominates Dan and Steven.
Dan goes to talk to Jessie and they make a tentative alliance. Memphis talks with Jessie about expanding their alliance and wants to bring in Angie and Michelle.
Steven tries to convince Libra, Keesha, April and Ollie not to vote him out. Dan returns to Jessie to make sure he really is safe. Julie asks the contestants to answer questions from the audience. Steven is unanimously voted out. Keesha wins the space themed HoH competition.
Keesha receives a note from home. She and Renny discuss strategy. The contestants pair up in guy/girl teams and play a sock/voice matching game for the food competition. Jessie and Memphis try to convince Keesha not to put Angie up for eviction. Keesha nominates Jessie and Angie for eviction.
Jessie goes up to talk to Keesha about being nominated and tries to explain his position on Steven. Keesha wins the PoV competition. Angie goes up to talk to Keesha about using the veto on Jessie and putting Libra up instead. Keesha decides not to use her veto and lets the nominations stand.
The houseguests experience an actual earthquake. Angie and Jesse try to win votes, but Angie is eliminated unanimously. Dan is secretly chosen to be "America's Player" for a week, and has the chance to win $20,000. A head-of-household endurance competition begins.
April wins the HoH competition by hanging on the wall the longest. Dan's mission as "America's Player" is to get Jessie nominated. He suggests the idea to April who is immediately suspicious and wonders if he is "America's Player." April announces that she's nominated Memphis and Jessie. Michelle hopes that April will keep her word and keep Jessie safe.
April and Ollie try to reassure Jessie that he's going to be safe. Dan, as America's Player, must hug Jessie for at least 10 seconds. April, Michelle, Jessie, Libra, Memphis and Jerry compete in the PoV competition. It's Keesha's birthday and the house celebrates. Jerry wins the Veto. Both nominees plead their case to Jerry, but he decides not to use the Veto and the nominations stand.
April still wants Memphis out and works to get people to vote her way. Dan struggles with his duties as America's Player. The votes are cast and Dan is the tie-breaker and as America's player must vote for Jessie. Jessie is eliminated. Michelle wins the HoH competition and vows to avenge Jessie.
April is frustrated that her plan was foiled. Michelle is excited to be HoH and in control. Michelle confronts Dan about his vote against Jessie. The houseguests play the food competition and end up on slop for five of the seven days, plus a feast one night. Michelle nominates Keesha and Libra.
Jerry goes to talk to Michelle and tells her that he is excited to play for the veto and that he believes Dan is America's Player. For the Veto competition the players must carry chopped onions and deposit them in either a Veto bin or a mystery prize bin.
Keesha worries that she'll be sent home. April campaigns against her. Libra breaks down and admits how much she wants to see her kids to Keesha and Renny. Julie talks with the contestants. Libra is unanimously voted out. Renny wins the HoH competition.
April and Ollie discuss strategy and Jerry keeps interrupting. Renny admits to Michelle that she doesn't like the Keesha and Memphis friendship. The red team of Dan, Michelle, April and Keesha win the food competition. Renny warns Dan that she may use him as a pawn. Ollie tries to convince Renny to put up Jerry. Renny nominates Jerry and April.
Renny, Dan, April, Keesha, Jerry and Ollie compete for the PoV. Dan wins. April tries to bribe Dan with money to use the Veto on her. Jerry offers his loyalty. Renny insists that Dan not use the Veto and in the he follows her request and lets the nominations stand.
The houseguests try to figure out who offered Dan the money. Ollie tries to convince Dan to vote Jerry out and then April approaches him about it as well, offering him money again. Things are becoming more serious between April and Ollie. April is voted off.
Dan and Ollie are the last two in the HoH competition; Dan makes a deal with Ollie, giving him the power to select one of the nominations and select a replacement if a veto is used. Dan wants to nominate Jerry and Ollie wants to nominate Memphis. Memphis talks to Dan about it and Dan feeling guilty goes to try to make sure he has enough votes to keep Memphis in the house. Dan announces the nominees are Jerry and Memphis.
Memphis lets Dan know that he's upset about being nominated. Dan assures him he's not going home. Keesha and Renny are also unhappy with Dan's deal. Jerry gets a phone call from his grandson.
Ollie is furious that Dan played him and he confronts Dan. Michelle is evicted from the house with Ollie being the only one voting to keep her in. Keesha wins the HoH competition. She nominates Jerry and Ollie. The players then head out for the veto competition which Dan wins. Dan chooses not to use the veto and the nominations stand. Ollie is voted out.
Jerry wins HoH. Dan and Keesha are nominated for elimination.
Dan tries to unsettle and annoy Renny, who is his target for elimination. Memphis wins the PoV. He uses the PoV to save Dan and Jerry is forced to put Renny up in Dan's place. Jerry is upset with Memphis for using the PoV on Dan.
Jerry stirs up trouble by trying to convince Keesha that Memphis has a deal with everyone in the house. Keesha asks Memphis about it and he lies to her. Memphis reveals to Dan that he has been taking his girlfriend for granted and wants to change that. Julie catches up with the jurors. Renny is voted out of the house and Dan wins the HoH competition.
The house guests return from the HoH competition to find a Sumo Wrester in the house. The wrestler has brought an envelope with info. about a special luxury competition.
Dan talks with Keesha and Memphis talks with Jerry each making alliances. Dan meets Michelle on the private island for his luxury trip and tries to win her over. Dan throws the PoV competition allowing Memphis to win. Keesha sees Dan and Memphis talking and asks them if they are evicting her. Keesha is evicted and as she leaves, Dan tells her that he took Michelle to the island with him.
Jerry, Dan and Memphis battle for the HoH title. Keesha joins the other jury members and they catch up. Dan wins the title of HoH. Dan evicts Jerry and Jerry is disgruntled about it. Memphis and Dan are excited that their alliance has taken them to the final two.
Dan and Memphis are treated to a special celebratory dinner. They reminisce about the events and drama in the house throughout the competition.
The jury unanimously votes Dan the winner of Big Brother 10. Keesha is America's favorite juror.