Blade teams up with a woman bent on revenge as he prepares for the ultimate battle against the Chthon, an ancient breed of vampire, who work towards complete domination of the human species.
When Marcus keeps Krista from leaving the house of Chton, she is forced to make her way without the help of Blade or Chen. With Krista unavailable to him Blade seeks proof of Marcus's vaccine through Reverend Carlyle, a link to the asher community.
Blade pursues a contact in the House of Arnaya who has information on Marcus's experiments.
Reverend Carlyle sets Blade up to get captured by the Bad Bloods, disenfranchized vampires Blade first turned and who were once his childhood friends.
Boone continues his killing rampage and pays a visit to Damek at the House of Armaya. Marcus sends Chase to Berlin to track down a pregnant important research subject. Blade intercepts the pregnant patient Vanessa to learn what she might have to do with Chthon's experiments.
Krista runs into Uncle Pat at a gale with Marcus and learns that her mother is ill. With Chase injured, Marcus sends Krista to get research subject Vanessa back from Blade.
Blade pursues the murder of Flanigan a cop who helped care for him growing up. In a flashback we see how young Blade ended up in the hands of Whistler when his father could no longer control his need to feed.
Chase meets up with an old flame, Alex, a wealthy pure blood who encourages her to leave Marcus. Blade and Krista try to track down Krista's mother who is on the loose.
Krista goes on a bender becoming unavailable to both Marcus and Blade. Blade discovers Marcus's experiment has more to do with the pure bloods. Krista finds out about Marcus's past life when she repeats her after death experience.
Blade and Shen track the White Prince, an infamous vampire serial killer. After feeding on Marcus Blade forces Krista into isolated detox. Pure blood Charlotte makes Chase a proposition.
Blade and Detective Collins team up to track Pure Blood Charlotte. Marcus makes plans to present his experiment at Pure Blood conclave.
Blade and Shen stake out the Pure Blood conclave to make Marcus's plan comes to fruition.