When a major university accepts a donation for environmental research from an oil company, Shirley Schmidt reneges on her own donation and is sued. Alan Shore defends her but is shaken when he meets Lorraine Weller, his opposition and an old flame.
While assisting Jerry Espenson and Katie Lloyd with a high profile murder trial, Alan struggles with his love life. Lorraine Weller is hired at Crane Poole & Schmidt, and Alan can't resist her. Neither can Denny. Meanwhile, Lorraine and Clarence Bell take on the case of a woman who, after having an affair with her pastor, is dumped and loses her faith. Judge Gloria Weldon awaits Alan's decision about fathering her baby.
Denny Crane is so convinced that Carl Sack will be on the losing side of a cockfighting case that he wagers an extremely large sum with him. Alan Shore and Lorraine Weller pursue a lawsuit against a high school, which teaches abstinence-only sex education, after a 15-year-old girl contracts HIV. Meanwhile, Katie Lloyd and Jerry Espenson take on the case of a woman who alleges that a psychologist's therapy sessions caused her husband's suicide.
When General "Fitz" Fitzgerald reveals his homosexuality and the army threatens to discharge him, he comes to Crane Poole & Schmidt for help. Denny is shocked by the truth about his old friend and Shirley agrees to take Fitz's case.
Alan Shore finds himself in a predicament when a woman, Patrice Kelly, asks his advice on how to kill the man who murdered her daughter and was acquitted by reason of temporary insanity.
Alan Shore attempts to prove that Patrice Kelly was temporarily insane when she killed the man who murdered her daughter. Meanwhile, everyone thinks Denny Crane has finally lost it when he fires an associate lawyer for being fat. Jerry Espenson helps an objectophile and fellow Aspergers syndrome sufferer locate her lost love- a utility box.
Alan Shore helps Denny Crane defend himself in court when he is sued for firing an associate for being fat. Whitney Rome and Katie Lloyd take on a murder case in which the DA plans to use a functional MRI as evidence to prove that the accused former cop is a racist.
Denny Crane is arrested in the courthouse men's room for allegedly soliciting an undercover officer in the next stall. He asks Alan Shore to defend him. Meanwhile, Shirley Schmidt takes on the case of a shock jock who was fired for making an inappropriate comment while on the air, and Katie Lloyd begins to question whether Lorraine Weller is harboring a dark secret.
After trying to sue the National Guard for not coming to the aid of a business that was flooded out during a storm, Alan Shore and Denny Crane decide that it's up to them to stop complaining and do something about it.
Carl Sack and Katie Lloyd defend the firm against a client who claims Denny Crane misled them about the environmental friendliness of the Crane Poole and Schmidt offices.
Denny Crane takes on a high-profile murder case and refuses help from Alan Shore. While Denny basks in the spotlight, Shirley Schmidt, Carl Sack and the rest of the firm fear the personal and professional embarrassment from Denny's latest crusade for relevancy.
Shirley Schmidt defends Missy Tiggs who, after being dumped by her husband, stole a man's semen and artificially impregnated herself. Shirley finds herself going up against Alan Shore when he's hired to represent the man whose seed was heisted. Meanwhile, Jerry Espenson defends ex-girlfriend Leigh a fellow Asperger's syndrome sufferer and objectophile when she loses her teaching position for hugging a student.
Shirley Schmidt asks Alan Shore to represent her friend Andrea, who wants to sue her town for planning to build a nuclear power plant. Alan and Denny Crane both fall under the spell of the sexually adventurous Andrea, as Shirley, for her part, discovers that the opposing team's attorney, Jack Rice, is an old college flame which doesn't go unnoticed by Carl Sack.
The sexually adventurous Andrea once again secures the services of Crane Poole and Schmidt and Carl Sack when she sues a company -- that was supposed to turn her mother's ashes into a diamond for misplacing the ashes and giving her a cubic zirconium instead.
Alan Shore and Jerry Espenson take on a tabloid talk show when a woman is murdered by her ex-boyfriend after declining his marriage proposal on television; and Shirley Schmidt defends a friend an unstable war hero -- for shooting seals for meals.
After her father, who is in the late stages of a debilitating fight with Alzheimer's, injures himself and lands in the hospital, Shirley Schmidt wants to end his suffering and asks Alan Shore to argue in court on her behalf. Meanwhile Jerry Espenson's beautiful, new girlfriend sues him for sexual assault, and Carl Sack represents the island of Nantucket whose residents want to build a nuclear bomb in case of attack.
Alan Shore gets the dream of a lifetime for an attorney when he is asked to present an appeal to the Supreme Court in the case of a mentally challenged man who has been sentenced to death for the rape of a young girl. Meanwhile, Katie Lloyd learns some startling news from Lorraine Weller about Jerry Espenson's new girlfriend.
Denny Crane falls hard for cattle rancher Sunny Fields, who hires him to sue the FDA in order to stop the sale of cloned meat. Meanwhile, when Shirley Schmidt's nephew a pledged delegate informs her that he's going to vote for another presidential candidate than the one his state voted for, she enlists the aid of Alan Shore to take him and the Democratic National Party to court.
Denny Crane is asked by some high ranking politicos to run for President of the United States. Meanwhile, Jerry Espenson's ex-girlfriend, Dana, asks him to defend her when she's arrested for prostitution, and Shirley Schmidt and Carl Sack represent a woman who is suing the Archdiocese for not allowing her to become a priest.
Patriotism abounds as Alan and Denny celebrate their acceptance into the Auxiliary Coast Guard. However, when the town of Concord, Massachusetts wants to secede from the United States and Alan takes the case, Denny is deeply offended. The case gets personal when Denny appears in court representing the opposing side.