A high roller poker player suddenly drops dead during a game and Grissom looks for foul play while Catherine and Nick investigate a murder in the world of illegal street racing.
When a famous actor is accused of murder, Grissom's investigation is put under the microscope to bolster the star's defense.
A wealthy couple is found dead while they are selling their house and a cheerleader is found dead, disembowled and the killer may have eaten her organs.
Grissom investigates a possible suicide when a dwarf is found hung at a little person's convention. Meanwhile, Catherine is attacked as she investigates a murder that occurred during a robbery.
When a woman who volunteers from the audience disappears during a magic show trick, the team's investigation is hampered by the magician's unwillingness to reveal the details of his illusion. Meanwhile a singer's apparent overdose also turns into a murder investigation.
When new evidence comes to light that may exonerate a convicted rapist and murderer that Catherine put away years ago, she reopens the case to find out the truth.
Fight night keeps the team exceptionally busy as they investigate a murder, a robbery and a fatal boxing bout.
As the team deals with a snuff film given them by a film processing lab, Nick and Grissom try to discover the identity of an ant-covered skeleton.
Sara and Grissom investigate the site of a car accident and a subsequent assault only to find evidence pointing to a third crime - involving a gun.
When a man is shot to death after an altercation outside his local bar, Catherine comes to suspect it was the result of a dispute between neighbors. Meanwhile, Warrick and Nick investigate the death of a man who seems to have fallen from the sky and realize he may have had a fatal paragliding mishap.
As Warrick and Sara check out the case of a young woman who apparently killed herself, Grissom and Catherine investigate the murder of a leading chef fed into his own industrial meat grinder.
A man suffers from a heart attack and ends up on the autopsy table only for the M.E. to discover he's still alive. Meanwhile, the team traces a human eyeball found in a bird's nest back to a murdered woman.
As Nick investigates the murder of a dot-commer, Warrick looks into the drive-by shooting in his old neighborhood.
It's a race against time as the investigators try to capture a serial rapist whose attacks are getting increasingly violent. Meanwhile, Sara takes it upon herself to reopen her prosecutor friend's case, hoping to track down the criminal who shot the woman's husband and wounded her three years ago.
As Catherine's daughter's life is endangered when she's trapped in a sinking car, Grissom's investigation into the untimely deaths of two male escorts brings him back into contact with dominatrix Lady Heather.
While part of the team tries to recover the kidnapped son of a pro basketball player, the others investigate a man who led police on a high speed pursuit, only to stagger from his car and collapse due to a wooden stake protruding from his head.
While Grissom and Nick look into a carbon monoxide leak in a residential neighborhood that led to a woman's death, the rest of the team examines a scene where a car crashed into a restaurant.
As Warrick and Grissom look for a missing camper, a murder investigation takes the rest of the team into the world of robotic sports.
While Grissom and Catherine look into the death of a movie patron apparently stabbed while in the theater, the rest of the team finds themselves stymied in the case of teenager felled by a gunshot wound.
The team finds it eerily coincidental when the death of a comedian resembles another case on the other side of town.
Catherine and Grissom investigate the case of a trainer who died when he was trampled by a racehorse in the cargo hold of a private jet.
While dealing with the fallout of an explosion in the CSI lab, the team must investigate how a woman was strangled to death in a high school press box.
As Grissom's continued loss of hearing brings him to a major decision, the team loses a member during a bank robbery and shoot out.