Mac and the team find human blood on the crown of the Statue of Liberty, leading them on a race against time to save a famous musician from death at the hands of a vigilante.
A body found in the New York harbor leads Mac and the CSIs to a hidden treasure that turns out to be fake and puts Sheldon in a dangerous situation. Upon further investigation the team learns the treasure was a distraction for an assassination plot on a diplomatic convoy headed to the U.N.
A group of "Bond-like" thieves are robbing law enforcement in Manhattan.
A dying man confesses to a murder 24 hours before it happens and Mac investigates the possibility of time travel. Stella investigates a case of a woman dying due to complications from a test drug that was switched with her asthma inhaler medication. Meanwhile, Mac encourages Stella to give the guy from the antique store a shot and he gets a letter from Peyton breaking up with him.
A woman's murder sends Mac into "Second Life," the internet-based virtual world to track down the killer in both the real and cyber world.
Lindsay investigates a mass murder at the infamous Amityville Horror house and Stella and Mac work on a murder in the mist of a zombie gathering.
Mac and the team find a man stabbed to death in Madison Square Park and a woman shot dead on the steps of the Metropolitan Museum of Art, and they soon realize that the two victims have a criminal past in common.
When a supermodel is found dead in a giant martini glass on a Times Square billboard, the CSI team follows the evidence in search of the party crasher. When they learn she was killed by a poisonous jellyfish, they follow the trail and learn that the supermodel was not the target. Meanwhile, Stella has a date with the man from the antique store.
Mac investigates a groom murdered on his wedding day, found stuffed and wrapped like a wedding present. Meanwhile, Stella finds a box of bloody puzzle pieces left on her car.
A member of the CSI team is taken hostage as Mac closes in on his stalker and learns the significance of the number 333.
When the CSIs investigate a murder victim, the clues lead them to an infamous seller of killer pranks, "Laughing Larry." Meanwhile, Danny works on a case involving a boy from his neighborhood.
Mac and the team investigate when a much-hated hotel owner is found buried beneath a New York ice sculpture, and a school bus driver accidentally hits a woman walking down the highway in her nightgown.
Mac investigates the murder of a woman outside a floral shop and the homicide of a judge located two buildings down. The team must determine how the murders are connected and who wanted to kill the judge. Meanwhile, Danny tries to stop his neighbor from going after her son's killer with Danny's gun.
A drowning victim falls out of a self-cleaning restroom. Although initially it appears to be a freak accident, the CSIs believe foul play was involved and investigate.
Working with an anonymous tip, the CSIs travel to an abandoned warehouse and back into the virtual world where they hope to find one of the city's most-wanted criminals.
When a fire breaks out in Stella's apartment, the CSIs investigate and determine it was arson.
The CSI team inspects a twisted trail of evidence when a salesman washes up on Rockaway Beach along with several dead sharks.
The CSI team investigates the mysterious death of a handsome guidance counselor at a high school prom. Their surprising discovery of an adult rapist posing as a student, leads to another murder. Meanwhile, Mac faces pressure to bring someone in for questioning on the "Taxi Cab Killer" case.
Another victim of the "Taxi Cab" killer shows up. Mac's wife's son, Reed starts reporting on the killer and goes to meet with a source. He ends up getting in the cab with the killer. Lindsay works on the murder of a fan at a basketball game by a cheerleader. Meanwhile, she struggles with her feelings for Danny.
Reed's blog accuses a man of being the "Cabbie Killer" and then the man shows up dead. When Mac goes to confront Reed about his source, he finds Reed missing. As the team searches for him they learn that the real "Cabbie Killer" is on the loose and he has Reed. As Reed begins posting to his blog from captivity, Stella and Mac use the clues he's giving them to track down where the killer is holding him.
When a heist goes bad and a bank manager is shot dead, the frantic gunman takes the entire bank hostage and demands a CSI come in to prove his innocence.