Barri has to go to the bathroom and goes in the bushes and then sees into the men's locker room. Campus security catches them and they have to talk to their advisor. They play truth or dare with their friends. Barri's dare is to shoplift, and Joan's is to have a three-way. They both get caught and get in trouble.
Barri starts dating a college boy, while Joan has a crush on a professor. Barri convinces Joan to wear a thong to impress the professor, but the plan backfires. Then Barri sets Joan up with a magician who is friends with her boyfriend. Joan talks to the professor. Barri's new boyfriend dumps her.
Barri finds out that her ex-husband is not paying for her college anymore so she has to find a way to make the money. She agrees to let Abdul put a web cam in her room to make more money. When her roommates find out they are upset. Meanwhile, Joan wants to get her yearly mammogram, but discovers that the college health services do not provide those. Joan uses the money Barri gives her to get a mammography machine for the college.
Barri and Joan have to pretend to be disabled for a week as a class assignment. Barri pretends to be blind and Joan pretends she can't walk. However, the ladies take the experiment too far and don't quite learn the lesson the experiment was designed to teach.
When the other sororities refuse to let them rush, Joan and Barri try to join the African American sorority on campus.
Barri and Joan's psychology teacher tells them that they are co-dependent, so Joan decides she needs to branch out and make other friends. Paige's father shows up after his wife leaves him, which causes Paige more stress than she admits. Roger, Barri's ex-calls her about the divorce papers and then comes to college to see her.
Joan hurts her neck leading her and Barri to go on a crusade for safety on campus. They block the shower. Paige talks to Drew about their relationship. Paige tries to get drugs for her friends, so Barri decides she and Joan should get the drugs for Paige to get back on her good side. They set up a safe room to do the drugs in. Meanwhile, Abdul has a party to get a girlfriend.
Barri and Joan join a Christians group because they like all the good food at the meetings. Abdul makes Drew a fake ID. Drew gets sick from some medical experiments he's doing to get Miranda the bag that she wants for her birthday. Abdul tries to get Lisa to have sex with him. Abstinence is the topic of the retreat that Joan and Barri attend.
Joan and Barri try to play pranks with their fellow college students. The ladies mothers come for a visit since the Joan and Barri are working on their family histories. Barri finds out that she is a descendant of Hitler. Joan finds out that she's not really adopted.
Joan and Barri hire a Asian transfer student to help them study for their math exam so that Barri can pass the class. Unfortunately the ladies get distracted trying to get the tutor to loosen up. Meanwhile, a flasher runs around campus and Drew is upset to learn that he is the worst lover Miranda has had. Barri runs into Marshall again and falls for him, but he breaks up with her again even though they aren't dating.