The neighborhood is shocked with news about Edie's attempted suicide. After making a recovery, she puts her plan into action to make Carlos stay with her.
After Lynette kicks Tom out of her chemotherapy sessions, she asks her friends for help. She is surprised when Gaby doesn't volunteer. Susan is torn between Mike and Julie. Katherine upsets Bree by switching out Bree's pie with hers. Bree attempts to steal the secret recipe and learns that Katherine has even bigger secrets to hide. Edie asks Carlos to marry her.
Bree informs the housewives of what she overheard in the Mayfair house. Stella makes some special brownies to help Lynette through chemotherapy. Susan throws a charades party for the whole neighborhood.
Edie is shocked when she receives some news at the gynecologist's office, an unexpected visitor discovers Bree's pregnancy is a hoax, and Wisteria Lane welcomes new neighbors who happen to be partners.
Bob and Lee's contemporary water sculpture in their front yard prompts the Wisteria Lane neighborhood association into action. Edie finds out about the affair that Carlos is having with Gabrielle. John Rowland, the Solis' former gardener, wants to rekindle his romance with Gaby.
Edie Britt's biggest fear comes true when Carlos walks out on their relationship and she can't prove he embezzled any money. Upset, she shows incriminating pictures to Victor. Susan finds out Mike's father is not dead, he's in prison for murder. Danielle shows up unexpectedly at a neighborhood Halloween party. She gives birth that night at Bree's house. Lynette finds out that her treatment worked and she is cancer free.
Victor confronts Gaby about her affair with Carlos while they are out on his boat. Afraid Victor is going to kill her, Gaby knocks him overboard. Bree informs Susan that she thinks Mike is addicted to drugs. Bree wants the new Hodge baby circumcised, but Orson is strongly against it. Lynette tries to get her mother to live with one of her sisters.
Adam Mayfair is shocked when a mysterious stalker from his past shows up on Wisteria Lane. Bree and Orson encounter martial problems with a new baby in their lives. Lynette reunites with her long lost stepfather. Carlos and Bree disagree on whether or not to call the cops about Victor. But then Victor shows up in a stable condition, unconscious.
The residents of Wisteria Lane are forced into basements, cellars and safe rooms to weather a tornado that destroys homes and lives forever. Carlos and Gaby try to move out of town, and away from Victor, before the storm hits.
Mrs. McCluskey's house completely destroyed, Lynette faces the possibility that her family may have not survived. They do survive, but Ida Greenberg, who saved them, does not. Katherine finds out that someone knows the truth about her mysterious past. The residents of Wisteria Lane begin to rebuild their lives after the deadly tornado. Bree and Orson move in with Susan and Julie.
Katherine Mayfair is unable to keep some of her secrets from the women of Wisteria Lane, Susan's hunky young male cousin reveals more than expected, and a surprise wedding ceremony has its share of secrets.
Gaby struggles with the reality of having a blind husband. Lynette is surprised when someone from her past shows up at Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball.
Bree and Katherine decide to start a business together. Mike learns the truth about his nearly fatal accident. While Lynette struggles with feelings of suspicion about Tom regarding the fire at Rick's restaurant, Gaby struggles to adjust to Carlos's new seeing-eye dog.
Lynette punishes her boys for starting the fire at Rick's restaurant but soon learns it was Kayla who gave them the idea. Bree gives Orson an ultimatum - either turn yourself in or get out. Susan reconnects with her ex-husband Karl when she sees him with his new young bride at Lamaze class.
Adele Delfino, Susan's mother-in-law, arrives for a visit. Carlos and Gaby find out their tenant, Ellie, has a dark secret. A full scale war erupts between Bree and Edie.
In part 1 of the season finale, the ladies of Wisteria Lane meet Susan and Mike's new baby. Gaby forms a strong bond with their new tenant, Ellie. Lynette is accused of child abuse.
In part 2 of the season finale, several residents of Wisteria Lane are faced with deadly threats. Susan realizes she will soon lose someone she loves. Katherine Mayfair's secrets are finally revealed.