The 1992 L.A. riots find trauma surgeon Doogie (Neil Patrick Harris) overwhelmed. Raymond: Markus Redmond. Thomas: Garvin Funches. Rita: Sheila R. Johns. Pat: Julie Ow.
Katherine can't stop playing mother to Doogie, even after he dates her boss (Kristen Cloke), whom he brings to the house for skinny-dipping. Belinda Montgomery, Neil Patrick Harris.
After the family is robbed, Doogie considers buying a gun, but he's haunted by memories of shooting victims he's treated. Off. Scott: Ron Canada. Crandall: Art La Fleur. Salesmn: Wayne Powers.
Doogie (Neil Patrick Harris) hunts for new digs---a Venice Beach loft; and Vinnie must also find a new home when his parents divorce. Candy: Miriam Flynn. Harold: Max Gail.
A med-school project has Doogie and a fellow doctor (Maggie Jakobson) posing as patients, being poked, prodded and probed to learn how to empathize with patients. Karen: Emily Warfield.
Doogie faces his first solo surgery fearing he's not perfect; and Vinnie faces his first time voting. Dr. Angelis: Ray Abruzzo. Dr. Meyerson: John Ingle.
Doogie's ego takes a beating when a winsome nurse (Eva Loseth) chooses Vinnie over him. Raymond also comes up short when comparing himself to other technicians. Nick: Ray Lykins.
A hearing-impaired patient (Terrylene) charms Doogie, who speaks her language by signing but may not be listening. She also offers creative inspiration for Vinnie's Chaplinesque film. Max Casella.
Doogie's heart tells him to do one thing, his head another in choosing the best candidate for a heart transplant; and Vinnie's dilemma involves a vulnerable Janine (Lucy Boryer). Jack: Joel Polis.
Doogie holes up at the hospital on Thanksgiving Eve for some R&R, as does a new mother (Gail Edwards) who feigns illness to get away from her family. Dr. Winston: Bren McKinley.
Doogie spots evidence of child abuse when his dad's friend brings in his injured son (John Christian Graas) for care. Hank: Stephen Lee. David: James B. Sikking. Harris: Demetria Victor.
Doogie's mom makes a poor substitute as Doogie's fishing partner when Dr. Howser throws his back out and is at home being cared for by Vinnie (Max Casella).
Doogie learns a lesson about trusting the unknown from a free-spirited model (Cristan Crocker) sharing his loft, as does a kidney-transplant candidate (James Pickens Jr.) Jerry: Dirk Blocker.
A nurse Doogie's dating retaliates against his braggadocio by spreading rumors about him; Vinnie gets a new film-school dormmate (Gil Cates Jr.). Welch: Rif Hutton.
Vinnie can't adjust to the masseuse (Donna Ponterotto) his father (Don Calfa) is dating; Doogie's dad is asked to replace a doctor who expired while on duty. Dr. Horschlauer: Patrick Cronin.
Doogie as Sherlock Holmes and Vinnie as Dr. Watson play out Doogie's confusion over Michele. Spaulding: Kathryn Layng. Bob: Robert Clotworthy. Doogie: Neil Patrick Harris. Vinnie: Max Casella.
Laura (Eva Loseth) makes Vinnie feel he's "become a man," but he reacts with adolescent jealousy to men around her. Meanwhile, a traveler's illness puzzles Doogie. Kelly: Tracy Scoggins.
Some things are better left unexplored, like Doogie's crush on his old baby sitter (Chelsea Noble) or Vinnie's dream of having a star (Jeff Yagher) read his script. Young Doogie: Matthew Boyett. Dr. Welch: Rif Hutton. Stage Guard: Steve Eastin.
A deposit error dumping $16,000 in Vinnie's account tests his integrity; and Doogie must prove his integrity to a girl (Shiri Appleby) with a crush on him. Mr. Dickson: Gibby Brand.
Doogie bemoans his friendship-only status with Michele (Robyn Lively) but finds inspiration on how to deal with it from an acerbic cartoonist patient (John Vernon). Tom: Ken Olandt.
Jury member Vinnie tries to look beyond the letter of the law, as does Doogie, who uncovers a bogus doctor at Eastman. Randall: Alan Young. Judge Bancroft: Lincoln Kilpatrick.
Doogie sees his gift of genius as more of a curse than a blessing as he seeks inspiration outside the world of medicine. Jenny Jones appears as herself. Anne: Tricia O'Neil. Chris: Scott LaRose.