When an ambulance explodes, Abby wakes up and realizes that she has been injured. In a selfless act, she rushes to check on the others in the ambulance. A mother and daughter are also brought in due to the explosion, and Abby misdiagnoses the case. Meanwhile, Morris and Neela struggle to keep up with the injuries sustained from the explosion.
Banfield's attitude causes the whole ER staff to feel defensive. Gates and the new interns attempt to save the life of a terrorist while risking their own. Neela finds an advocate in her fight to get Dr. Dubenko back on the surgery staff.
Neela finds out Abby's good news second hand. Catherine Banfield and Abby butt heads on how to treat the victim of a gun shot wound, that has just been admitted into the ER. Finally, Abby comes to Sam's defense before a nurses' disciplinary board.
When Banfield runs out to get a cup of coffee, she's caught off guard by a man trying to steal her wallet. Dr. Dubenko is back on the surgery team thanks to Dr. Brenner, and a young gymnast arrives at the ER after a fall, but Banfield and Gates think a family member may have caused the injuries. Meanwhile, Gates gets upset when he finds out that Sarah got her tongue pierced.
Gates feels neglected because Sam is distracted while studying for her pharmacology exam. A stab wound victim comes into the ER after a school fight and Brenner tries to get to the bottom of the story. Morris surprises Neela with an unexpected visit from Ray Barnett. Meanwhile, it's Halloween and Gates gets locked in a stairwell with a quiet, young boy.
Morris takes Chaz under his wing and teaches him some sensitive medical procedures much to the disappointment of Dr. Banfield. Neela gets angry when Dr. Banfield challenges her authority with one of the interns. Meanwhile, Gates goes over the line with Sam.
When Banfield takes a run she finds herself trying to rescue a three-year-old girl from drowning. Meanwhile, Gates tries to pull some strings to help a homeless war hero and friend. Later, the interns continue with their struggle to keep up in the fast paced ER.
Sam gets frustrated with Gates when he becomes obsessed with finding a homeless war hero. Neela is upset at her intern after he gets the entire surgery department into a lawsuit. A husband and wife come into the ER after someone tried to burn down their home. Brenner loses his cool with a patient and it gets physical.