When Brian starts to date Meg's teacher, Peter turns to James Woods for friendship. Things reach a boiling point between the two when Brian's girlfriend wants the school (James Woods High School) renamed. Stewie is intrigued by "The Da Vinci Code."
Peter and his friends become stranded on a deserted island. Peter finds that home life has changed in his absence and Lois is married to Brian.
Chris runs away from a high school Freshman hazing, but Peter eventually finds him in South America where, with the thirty-seven dollars in his wallet, he is the richest man in the country.
Peter starts a television broadcast but then comes under the scrutiny of the F.C.C.
Brian's local paper article draws the attention of the New Yorker, but is fired after they find out that Brian didn't finish college. Brian goes back to school and Stewie tags long.
When Lois feels that Stewie is acting out because he lacks a connection with his dad, they bond over doing harm to Lois. Their bonding culminates with a trip to a theme park where Stewie becomes enslaved as one of the singing children on a ride. Also, Chris breaks Herbert's window and must work it off mowing his lawn and they too form an less natural bond.
Peter starts a group for fat people and bands them together to stave off Lois' long-lost, crazy brother Patrick.
A visit from Peter's father causes Peter to examine his own faith, which he then places in the Fonz. Stewie falls ill when Peter allows his father to baptise him in contaminated Holy Water.
Brian's close brush with death, after Peter runs him over with the car, gives him a renewed joy in living.
Peter's reunion rouse is foiled by the appearance of Tom Brady who sees his football potential. Unfortunately, Peter's showboating leads to his defeat. Brian pays dearly for a gambling debt to Stewie.
Peter goes on a game show and wins a maid for a week, but Quagmire falls in love with her and asks her to marry him, only to later regret giving up his single, womanizing ways. Meanwhile, Lois tries to get Stewie off of breastfeeding.
Peter has a vasectomy after Lois mistakenly thought she was pregnant, but he soon loses his will to have sex entirely after the process. Peter soon finds himself interested in Lois once again after she acquires an overeating habit. Meanwhile, Stewie and Beltram battle for playground domination.
Brian tries to convince Meg that Mayor West is just another crooked politician when she accepts an internship position with his office. Brian and Stewie's attempt to expose him, however, leads them to a startling discovery about Meg's involvement in West's dealings. Meanwhile, Chris is forced to stop Peter and Lois from returning to their folk-singing days.
Peter is inspired to write an erotic novel which Carter publishes. But when Peter's audio version of the book gets Carter in legal and financial trouble, he is reduced to the lowly middle class. Also, Chris suddenly turns into a genius and challenges Stewie as they both try to take over the world.
Brian’s gay cousin has announced that he is engaged. In addition to his announcement, he also adds that he would like to be married at their house. But when the mayor bans gay marriage in order to cover up a scandal, Brian becomes a gay rights activist, Lois questions her homophobia and Chris joins a Republican extremist group.
After an accident lands Brian in the hospital, he has a near-death experience that leads him to take a new lease on life. He finds a passion for singing and develops a new nightly gig with Frank Sinatra Jr., but his "live in the moment" lifestyle only goes so far.
After Joe builds a new home theater system, Peter tries to top it by building a multiplex in his backyard and discovers an Indian burial ground. But when he takes an Indian chief's skull, the house becomes haunted and Stewie gets sucked into the television.
When the Griffin's find themselves being robbed they retreat to a panic room where Peter reveals the origin of the family name.
After a competitive swim lesson, Stewie tries to destroy his rival by blowing up the lifeguard tower. But when his plan backfires and he has a near-death experience, Stewie turns to the bottle to numb himself.