House has recovered from multiple gunshot wounds and is back at work, taking on two cases simultaneously: Richard, paralyzed after brain cancer surgery eight years ago, who drove himself on his motorized wheelchair headfirst into a swimming pool; and Caren, a young woman paralyzed from the neck down after a yoga session.
House's ego takes a blow when he fails to diagnose a patient. When this failure begins to affect him physically, a stubborn House takes on his next case.
Now that the medicine has worn off, House is back to using his cane and doesn't want to talk about it. His new patient is Ezra Powell, a renowned medical research pioneer who collapsed in his lab.
House takes the case of Adam, a 10-year-old severely autistic boy who screams loudly for no apparent reason. The team wonders why House is taking the case.
House takes on the case of 20-year-old female patient Tracy Dawson, who is rushed to Princeton Plainsboro Teaching Hospital with breathing difficulties and unexplained intense abdominal pain after she and her husband, Jeremy, are victims of a robbery.
A 600-pound man, George Hagel, is admitted to the hospital after he is found in his apartment in a coma. While they conduct the necessary tests, the team runs into several obstacles due to the sheer mass of the patient, and while sedated and undergoing an MRI, George suddenly awakes in a panic and struggles to get free.
Kyle comes to the hospital regularly to visit his father, Gabe, who has been in a coma for 10 years. Noticing something "off" about Kyle, House conducts a mini-experiment that leaves the boy unconscious.
House's newest patient is 18-year-old Jack, brought to the hospital after experiencing a heart attack and massive vomiting. Barely an adult himself, Jack has been the parent to his younger brother and sister since their parents died.
House and the team take on the case of Alice, a young girl with pancreatitis. Since her divorced parents can't agree on how to proceed with her treatment and won't let House bully them into making a decision, House's only option is to take them to court and let a judge rule on the matter.
It's Christmas at Princeton-Plainsboro and Wilson has a present for House. He and Detective Tritter have struck a deal and House has three days to accept it.
House is forced to respond in court to the criminal charges against him regarding illegal possession of narcotics, and the judge sets a date for a preliminary hearing.
House has beaten the drug charges and is back at the hospital after a short stint in rehab. Cuddy comes to collect on Houses debt for perjuring herself on the stand and keeping him out of jail.
16-year-old Stevie Lipa is admitted to Princeton Plainsboro Teaching Hospital with a serious respiratory condition and internal bleeding. Oddities of his case land him under House and the team's care, but at the moment, House is irritated to learn that new hospital researcher Dr.
Its Valentines Day at Princeton-Plainsboro and the ER is short-staffed due to a snowstorm. House encounters Foreman's latest patient, Hannah, who has sustained injuries from a car accident with her mother, Abby.
Patrick Obyedkov, a 35-year-old musical savant, is in the middle of playing a piano concert when he suffers a painful involuntary muscle contraction in his left hand.
House is puzzled yet intrigued when he meets his newest patient, John Kelley, an ex-Marine who had saved House’s life in a realistic dream just the night before.
A famous, pregnant photographer, Emma Sloan, is brought to the hospital after suffering a stroke in the middle of a photo shoot with Tyson Ritter. Although Emma’s condition initially stabilizes, her health takes a turn for the worse when her kidneys inexplicably fail.
Dr. Gregory House and Cuddy board a flight back to the United States from Singapore, where they were speakers at an international conference. Shortly after takeoff, a passenger seated next to House becomes violently ill.
The team takes on the case of 6-year-old Lucy, who collapsed at daycare. They discover that the tissues surrounding Lucy’s heart have hardened and are strangling her heart, a condition usually found in much older patients.
The team takes on the case of Lupe, a young female swindle artist, who passes out while working a card-playing scheme on the streets. Lupe suffers from a lack of blood to the brain, which had temporarily paralyzed her ability to make decisions or exercise free will.
Wilson prepares his 14-year-old leukemia patient, Nick, for a last-resort bone marrow transplant from his younger brother, Matty. However, when Matty sneezes during a pre-op visit to his brother, Wilson knows that Matty is not healthy enough to donate.
Foreman hands in his resignation, while the team races to diagnose Addie, a 19-year-old girl, who is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. The team is in a dilemma as to whether to save her life or to diagnose her disease.
16-year-old chess prodigy, Nat, is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament. House suspects his behavior as a symptom of cluster headaches. Meanwhile, Foreman’s frustration with House reaches a new level when he believes House sabotaged his job interview with another hospital, and Cuddy makes Foreman an offer she's sure he cannot refuse.
A Cuban couple, Esteban and his sick wife, Marina Hernandez, are pulled from the ocean during a dangerous rescue at sea while on route to the U.S. on a mission to reach Dr.