House has to work fast to diagnose a young woman, Megan, after a building collapses on her. Due to her injuries, Megan's only form of communication is blinking.
House is interviewing potential team members and is doing it his own way. He has called in all 40 applicants for the open spots on his team, each numbered individually by runners' bibs, and puts them to the test in a Darwinian trial period.
House splits the final 10 fellowship candidates into two teams, for some healthy competition. They are assigned to diagnose and treat a wheelchair-bound man with muscular atrophy, who is slowly suffocating.
A 20-year-old funeral home cosmetician, Irene, has a massive seizure and she hallucinates that the cadavers in the funeral home have come to life. House and the remaining seven fellowship candidates must figure out why.
The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac.
House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi, who offers up very little information about the agent's history or previous assignments.
A documentary film crew is chronicling a teenager with a major facial deformity who opts to undergo a dramatic reconstructive procedure. When the patient suffers a heart attack just prior to the surgery, House and the team are called in to determine the cause, since the surgery cannot proceed until the patient's cardiac condition is diagnosed.
House encounters a magician whose heart failed while performing an underwater escape act. While the remaining fellowship candidates work to diagnose the illusionist, House is determined to prove that he's a scam artist faking his ailments to cover up the fact that he nearly drowned during his act.
Cuddy puts the pressure on House to choose the final members of his team. House deliberately assigns the candidates to a particularly challenging case of an uncooperative, over-the-hill former punk rock star with a history of drug abuse and civil disobedience.
House and the team treat a woman who suffers from a sudden paralysis of the hands that causes an injury to her daughter while she's spotting her at an indoor rock-climbing wall.
When Dr. Cate Milton, a psychiatrist trapped at the South Pole and the research station's only doctor, becomes ill in the middle of her assignment, she and Dr.
The Team encounters a woman admitted to Princeton-Plainsboro after she collapsed at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play.
House suspects an emergency room patient has a bigger problem then the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom.
House is convinced one of the actors on his favorite soap opera "Prescription Passion" has a serious medical condition, after observing his symptoms on television.
House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House becomes convinced through his flashbacks that a fellow bus passenger was exhibiting signs of a deadly illness prior to the crash.
House remains inhibited by injuries sustained from a bus accident that has also left Amber rapidly deteriorating from a mysterious condition. Clues inside House's head hold the key to a her condition, and House's friendship with Wilson is tested beyond limits as murky memories from the bus accident the night before threaten to change their lives forever.